?-Trimethylsilylmethylamine Radical Cation in the Synthesis of Cyclic Amines and Beyond

Authors

  • Ganesh Pandey Division of Organic Chemistry National Chemical Laboratory Pashan Road, Pune 411008, India, Molecular Synthesis Laboratory, CBMR Sanjay Gandhi Post-graduate Institute of Medical Sciences, Campus Raebareli Road, Lucknow 226014, India. gp.pandey@ncl.res.in
  • Debasis Dey Division of Organic Chemistry National Chemical Laboratory Pashan Road, Pune 411008, India
  • Smita R. Gadre Division of Organic Chemistry National Chemical Laboratory Pashan Road, Pune 411008, India

DOI:

https://doi.org/10.2533/chimia.2013.30

Keywords:

α-amine radical, Glycosidase inhibitors, 1-n-iminosugars, Photoinduced electron transfer (pet), α-trimethylsilyl methylamine radical cation

Abstract

The evolution of chemistry associated with the photoinduced electron transfer (PET)-generated ?-trimethylsilylmethylamine radical cation cyclization to a tethered olefin to synthesize cyclic amine structural frame works is presented in chronological order. The importance of this interesting chemistry is demonstrated by the synthesis of several novel glycosidase inhibitors.

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Published

2013-02-27

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