Peptide-based Synthetic Design, Construction and Morphology of Soft Structures

Authors

  • Sudipta Mondal Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur – 208016 (UP) India
  • Apurba K. Barman Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur – 208016 (UP) India
  • Sandeep Verma Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur – 208016 (UP) India; DST Thematic Unit of Excellence on Soft Nanofabrication, Indian Institute of Technology Kanpur, Kanpur – 208016 (UP) India. sverma@iitk.ac.in

DOI:

https://doi.org/10.2533/chimia.2012.930

Keywords:

Carbohydrates, Fibers, Peptide conjugates, Scaffolds, Self-assembly, Vesicles

Abstract

Peptide-based self-assembly offers a unique entry into the construction of soft structures with interesting material properties and functions. Aromatic amino acid-containing peptides are commonly employed as they exhibit high propensity to aggregate due to increased hydrophobic content, promotion of favorable secondary structures, planarity and the possibility of ?–? interactions. Incorporation of covalent scaffolds, stimuli-responsive handles and carbohydrate moieties augment beneficial characteristics to the resulting peptide conjugates. These modifications were shown to enforce self-association, elicit stimuli response and achieve improved hydrophilic properties, to name but a few.

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Published

2012-12-19

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Section

Scientific Articles

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