Reductive Cleavage of 2,2,2-Trichloroethyl Esters by Titanocene Catalysis
DOI:
https://doi.org/10.2533/chimia.2012.433Keywords:
Catalysis, Protecting groups, Radicals, Synthesis, TitanocenesAbstract
Esters are of widespread use for protecting carboxylic acids in organic synthesis. However, methods to cleave esters often employ harsh conditions. Herein, we report a new and mild method for the reductive cleavage of 2,2,2-trichloroethylesters (TCE esters). Our radical method employs Cp2TiCl as an electron transfer catalyst and Zn dust as stoichiometric reducing agent. It avoids the use of strong Brønstedt-acids as well as aqueous conditions and can be carried out at room temperature.Downloads
Published
2012-06-27
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Scientific Articles
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Copyright (c) 2012 Swiss Chemical Society
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How to Cite
[1]
A. Gansäuer, T. Dahmen, Chimia 2012, 66, 433, DOI: 10.2533/chimia.2012.433.