Recent Advances in Iridium-Catalyzed Asymmetric Hydrogenation: New Catalysts, Substrates and Applications in Total Synthesis

Authors

  • Adnan Ganić SCS-Metrohm Foundation Award for best oral presentation, Department of Chemistry University of Basel St. Johanns-Ring 19 CH-4056 Basel, Switzerland. adnan.ganic@unibas.ch
  • Denise Rageot Department of Chemistry University of Basel St. Johanns-Ring 19 CH-4056 Basel, Switzerland
  • Lars Tröndlin Department of Chemistry University of Basel St. Johanns-Ring 19 CH-4056 Basel, Switzerland
  • Andreas Pfaltz Department of Chemistry University of Basel St. Johanns-Ring 19 CH-4056 Basel, Switzerland

DOI:

https://doi.org/10.2533/chimia.2012.187

Keywords:

Asymmetric catalysis, Boron, Hydrogenation, Iridium, Natural products, P,o-ligands

Abstract

Iridium-catalyzed asymmetric hydrogenation has emerged as a highly efficient method for the synthesis of enantiomerically pure compounds. This account summarizes our recent efforts in this field. We have developed a new type of P,O-ligand that was successfully applied to the asymmetric hydrogenation of ?,?-unsaturated carbonyl compounds. Furthermore we have demonstrated the potential of known iridium catalysts in the hydrogenation of ?,?-unsaturated boronic esters. And finally we could demonstrate the utility of iridium-catalyzed asymmetric hydrogenation in the formal synthesis of the natural product Platensimycin.

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Published

2012-04-25

How to Cite

[1]
A. Ganić, D. Rageot, L. Tröndlin, A. Pfaltz, Chimia 2012, 66, 187, DOI: 10.2533/chimia.2012.187.