Antitumor Cyclic Hexapeptides from Rubia Plants: History, Chemistry, and Mechanism (2005–2011)

Authors

  • Si Meng Zhao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201, China; Graduate University of Chinese Academy of Sciences Beijing 100049, China
  • Bin Kuang State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201, China; Graduate University of Chinese Academy of Sciences Beijing 100049, China
  • Jun Ting Fan State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201, China
  • He Yan State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201, China; Graduate University of Chinese Academy of Sciences Beijing 100049, China
  • Wen Yan Xu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201, China
  • Ning Hua Tan State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201, China. nhtan@mail.kib.ac.cn

DOI:

https://doi.org/10.2533/chimia.2011.952

Keywords:

Antitumor, Cyclic hexapeptides, Rubia, Rubiaceae-type cyclopeptides

Abstract

Rubiaceae-type cyclopeptides (RAs), cyclic hexapeptides from Rubia plants, have shown potential antitumor activity in vitro and in vivo. Based on the review about plant cyclopeptides (Chem. Rev., 2006, 106: 840), this mini-review will highlight new progress on the discovery, synthesis, and mechanism of RAs isolated during 2005 to 2011, covering recent work in our group.
CHIMIA Vol. 65 No. 12 (2011): Chemistry in China

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Published

2011-12-14

Issue

Vol. 65 No. 12 (2011): Chemistry in China

Section

Scientific Articles

License

Copyright (c) 2011 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
S. M. Zhao, B. Kuang, J. T. Fan, H. Yan, W. Y. Xu, N. H. Tan, Chimia 2011, 65, 952, DOI: 10.2533/chimia.2011.952.