Cu(i)/Amino Acid Catalyzed Coupling Reactions of Aryl Halides and Nucleophiles: Applications in Large-scale Production

Dawei Ma; Yongwen Jiang

doi:10.2533/chimia.2011.914

Cu(i)/Amino Acid Catalyzed Coupling Reactions of Aryl Halides and Nucleophiles: Applications in Large-scale Production

Authors

Dawei Ma State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 LingLing Road Shanghai 200032, China. madw@sioc.ac.cn
Yongwen Jiang State Key Laboratory of Bioorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 LingLing Road Shanghai 200032, China

DOI:

https://doi.org/10.2533/chimia.2011.914

Keywords:

Copper-catalyzed coupling reactions, L-proline, Ullmann-type coupling reactions

Abstract

Amino acids can be used as ligands to promote Ullmann-type coupling reactions. This review briefly discusses how L-proline, 4-hydroxy-L-proline and N,N-dimethylglycine can serve as the ideal ligands for copper-catalyzed coupling of aryl halides with different nucleophiles. Seven examples of applications of copper/amino acid catalyzed reactions in large-scale preparations are described.