Bicyclic Peptide Antagonists Derived from Genetically Encoded Combinatorial Libraries

Authors

  • Christian Heinis Ecole Polytechnique Fédérale de Lausanne, EPFL, Institute of Chemical Sciences and Engineering, CH-1015 Lausanne

DOI:

https://doi.org/10.2533/chimia.2011.677

Keywords:

Combinatorial chemistry, Cyclic peptides, Encoded libraries, Peptide therapeutics, Phage display, Protease inhibitors, Serine proteases

Abstract

Ligands based on bicyclic peptides can combine favourable properties of antibodies (good binding affinity and target specificity) and small molecule ligands (stability, access to chemical synthesis, diffusion properties) and might be suitable molecular structures for the development of therapeutics. By using a combinatorial methodology based on phage display and a chemical cyclisation reaction, we are generating bicyclic peptide antagonists of protein targets with therapeutic applications in mind.
CHIMIA Vol. 65 No. 9 (2011): ISIC at EPFL

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Published

2011-09-30

Issue

Vol. 65 No. 9 (2011): ISIC at EPFL

Section

Scientific Articles

License

Copyright (c) 2011 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
C. Heinis, Chimia 2011, 65, 677, DOI: 10.2533/chimia.2011.677.