Access to Macrocycles with an endo Aryl Ether and an endo Aryl-Aryl Bond, Development and Application

Qian Wang; Jieping Zhu

doi:10.2533/chimia.2011.168

Access to Macrocycles with an endo Aryl Ether and an endo Aryl-Aryl Bond, Development and Application

Authors

Qian Wang
Jieping Zhu Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, CH-1015 Lausanne

DOI:

https://doi.org/10.2533/chimia.2011.168

Keywords:

Complestatin, Macrocycle, Macrocyclization, Snar reaction, Suzuki-miyaura reaction, Vancomycin

Abstract

Macrocyclization methodologies allowing access to macrocycles having an endo aryl ether and an endo aryl–aryl bond, especially those based on an intramolecular SNAr reaction and the Suzuki-Miyaura reaction, are summarized. Total synthesis of complestatin, a bis-macrocyclic natural product, featuring these two technologies are presented.