Access to Macrocycles with an endo Aryl Ether and an endo Aryl-Aryl Bond, Development and Application

Authors

  • Qian Wang
  • Jieping Zhu Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, EPFL-SB-ISIC-LSPN, CH-1015 Lausanne

DOI:

https://doi.org/10.2533/chimia.2011.168

Keywords:

Complestatin, Macrocycle, Macrocyclization, Snar reaction, Suzuki-miyaura reaction, Vancomycin

Abstract

Macrocyclization methodologies allowing access to macrocycles having an endo aryl ether and an endo aryl–aryl bond, especially those based on an intramolecular SNAr reaction and the Suzuki-Miyaura reaction, are summarized. Total synthesis of complestatin, a bis-macrocyclic natural product, featuring these two technologies are presented.
CHIMIA Vol. 65 No. 3 (2011): Hot Topics

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Published

2011-03-30

Issue

Vol. 65 No. 3 (2011): Hot Topics

Section

Scientific Articles

License

Copyright (c) 2011 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
Q. Wang, J. Zhu, Chimia 2011, 65, 168, DOI: 10.2533/chimia.2011.168.