Synthetic Vaccines from Tumor-Associated Glycopeptide Antigens

Authors

  • Ulrika Westerlind Gesellschaft zur Förderung der Analytischen Wissenschaften e. V. ISAS – Leibniz Institute for Analytical Sciences Otto-Hahn-Str. 6b, D-44227 Dortmund, Germany;, Email: ulrika.westerlind@isas.de
  • Horst Kunz Johannes Gutenberg-Universität Mainz Institut für Organische Chemie Duesbergweg 10-14, D-55128 Mainz, Germany;, Email: hokunz@uni-mainz.de

DOI:

https://doi.org/10.2533/chimia.2011.30

Keywords:

Antibodies, Antigens, Glycobiology, Glycopeptides, Glycosylated amino acids, Immunology, Solid phase synthesis, Vaccines

Abstract

The aberrantly glycosylated and extensively over-expressed membrane-bound mucin MUC1 glycoprotein forms a tumor specific epitope on the surface of epithelial cells. Using defined synthetic glycopeptide structures consisting of the MUC1 tandem repeat region for immunization, antibodies selectively binding to tumor cell surface should be induced. Recent examples of synthetic vaccines directed against the O-glycosylated MUC1 tandem repeats and their immunological evaluation will be given here. These include synthetic MUC1 glycopeptides conjugated to immunostimulants, such as T-cell peptide epitopes, immune carrier proteins or lipid immunostimulants.
CHIMIA Vol. 65 No. 1-2 (2011): Glycochemistry Today

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Published

2011-02-23

Issue

Vol. 65 No. 1-2 (2011): Glycochemistry Today

Section

Scientific Articles

License

Copyright (c) 2011 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
U. Westerlind, H. Kunz, Chimia 2011, 65, 30, DOI: 10.2533/chimia.2011.30.