Studies toward New Anti-Cancer Strategies Based on α-Mannosidase Inhibition

Authors

  • Sandrine Gerber-Lemaire Werner Prize Winner 2010, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Batochime, CH-1015 Lausanne, Switzerland;, Email: Sandrine.Gerber@epfl.ch
  • Lucienne Juillerat-Jeanneret University Institute of Pathology, CHUV, CH-1011 Lausanne

DOI:

https://doi.org/10.2533/chimia.2010.634

Keywords:

Anti-cancer agents, Endothelial cells, Glioblastoma, α-mannosidase inhibitors

Abstract

Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumor progression, suggesting that inhibitors of selected glycosidases may control cancer progression. Following the studies on swainsonine, a natural inhibitor of Golgi α-mannosidase II, which highlighted the inhibition of cellular mannosidases as a potential innovative approach for the treatment of cancer, several dihydroxylated pyrrolidines and analogues were developed as new potent inhibitors of α-mannosidases II able to induce antiproliferative effects in human cancer cells.

Downloads

Published

2010-09-15

Issue

Section

Scientific Articles

How to Cite

[1]
S. Gerber-Lemaire, L. Juillerat-Jeanneret, Chimia 2010, 64, 634, DOI: 10.2533/chimia.2010.634.