Studies toward New Anti-Cancer Strategies Based on α-Mannosidase Inhibition
DOI:
https://doi.org/10.2533/chimia.2010.634Keywords:
Anti-cancer agents, Endothelial cells, Glioblastoma, α-mannosidase inhibitorsAbstract
Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumor progression, suggesting that inhibitors of selected glycosidases may control cancer progression. Following the studies on swainsonine, a natural inhibitor of Golgi α-mannosidase II, which highlighted the inhibition of cellular mannosidases as a potential innovative approach for the treatment of cancer, several dihydroxylated pyrrolidines and analogues were developed as new potent inhibitors of α-mannosidases II able to induce antiproliferative effects in human cancer cells.
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2010-09-15
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Copyright (c) 2010 Swiss Chemical Society
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How to Cite
[1]
S. Gerber-Lemaire, L. Juillerat-Jeanneret, Chimia 2010, 64, 634, DOI: 10.2533/chimia.2010.634.