Recent Biomimetic and Organocatalytic Syntheses of α-Tocopherol

Authors

  • Antoinette Chougnet Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel
  • Kegang Liu Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel
  • Wolf-D. Woggon Department of Chemistry, University of Basel, St. Johanns-Ring 19, CH-4056 Basel;, Email: wolf-d.woggon@unibas.ch

DOI:

https://doi.org/10.2533/chimia.2010.303

Keywords:

Chromane, Enantioselectivity, α-tocopherol, Tocopherol cyclase, Vitamin e

Abstract

We report here on our efforts to develop new strategies for the synthesis of α-tocopherol, the biologically most significant member of the vitamin E family. This review comprises five new methods to generate the chiral chromane of α-tocopherol with overall up to 29% yield from commercially available material and up to 94% de.

CHIMIA Vol. 64 No. 5 (2010): Hot Topics

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Published

2010-05-26

Issue

Vol. 64 No. 5 (2010): Hot Topics

Section

Scientific Articles

License

Copyright (c) 2010 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
A. Chougnet, K. Liu, W.-D. Woggon, Chimia 2010, 64, 303, DOI: 10.2533/chimia.2010.303.