Spectral Aliasing: A Super Zoom for 2D-NMR Spectra. Principles and Applications

Authors

  • Gaétan Bayiha Ba Njock Département de Chimie Organique, Faculté des Sciences, Université de Yaoundé I, P.O. Box 812, Yaoundé, Cameroun, Section des Sciences pharmaceutiques, Université de Genève, Université de Lausanne, Quai E. Ansermet 30, CH-1211 Genève 4, Département de Chimie Organique, Université de Genève, Quai E. Ansermet 30, CH-1211 Genève 4
  • Dieudonné Emmanuel Pegnyemb Département de Chimie Organique, Faculté des Sciences, Université de Yaoundé I, P.O. Box 812, Yaoundé, Cameroun
  • Trixie Ann Bartholomeusz Section des Sciences pharmaceutiques, Université de Genève, Université de Lausanne, Quai E. Ansermet 30, CH-1211 Genève 4
  • Philippe Christen Section des Sciences pharmaceutiques, Université de Genève, Université de Lausanne, Quai E. Ansermet 30, CH-1211 Genève 4
  • Bruno Vitorge Département de Chimie associé au CNRS, Ecole Normale Supérieure, 24 rue Lhomond, F-75231 Paris Cedex 05, France
  • Jean-Marc Nuzillard Institut de Chimie Moléculaire de Reims, CNRS, UMR 6229, Université de Reims, Campus du Moulin de la Housse, F-51687 REIMS Cedex 2, France
  • Rupali Shivapurkar Département de Chimie Organique, Université de Genève, Quai E. Ansermet 30, CH-1211 Genève 4
  • Mohamadali Foroozandeh Département de Chimie Organique, Université de Genève, Quai E. Ansermet 30, CH-1211 Genève 4
  • Damien Jeannerat Département de Chimie Organique, Université de Genève, Quai E. Ansermet 30, CH-1211 Genève 4;, Email: damien.jeannerat@unige.ch

DOI:

https://doi.org/10.2533/chimia.2010.235

Keywords:

Heteronuclear 2d nmr, Hsqc-based experiments, Nmr titration, Spectral aliasing, Structure determination of natural products

Abstract

The NMR methodology based on spectral aliasing developed at the University of Geneva is reviewed. Different approaches aimed at increasing the resolution in the indirect carbon dimension of 2D heteronuclear experiments are presented with their respective advantages. Applications to HSQC, HMBC and other 2D heteronuclear experiments to the study of natural products and synthesis intermediates are shown. HSQC-based experiments for diffusion measurements, kinetics studies and titrations experiments all take advantage of spectral aliasing to reduce the experimental time from unrealistically long acquisition times to overnight experiments. The roles of computational methods such as DFT/GIAO and Logic for Structure Determination (LSD) in structure determination are discussed.
CHIMIA Vol. 64 No. 4 (2010): Young Academics in Switzerland Part III

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Published

2010-04-28

Issue

Vol. 64 No. 4 (2010): Young Academics in Switzerland Part III

Section

Scientific Articles

License

Copyright (c) 2010 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
G. B. B. Njock, D. E. Pegnyemb, T. A. Bartholomeusz, P. Christen, B. Vitorge, J.-M. Nuzillard, R. Shivapurkar, M. Foroozandeh, D. Jeannerat, Chimia 2010, 64, 235, DOI: 10.2533/chimia.2010.235.