An Efficient Entry to Planar Chiral Organometallic Complexes via Pd-Catalyzed Asymmetric Hydrogenolysis

Authors

  • Audrey Mercier
  • Wee Chuan Yeo
  • Xavier Urbaneja
  • E. Peter Kündig University of Geneva, Department of Organic Chemistry, 30 Quai Ernest Ansermet, CH-1211 Geneva 4

DOI:

https://doi.org/10.2533/chimia.2010.177

Keywords:

Catalytic desymmetrization, Chromium, Hydrogenolysis, Planar chirality, Ruthenium

Abstract

Planar chiral chromium- and ruthenium-based arene complexes were prepared with high levels of enantioselectivity via a Pd-catalyzed asymmetric hydrogenolysis reaction using a bulky chiral phosphoramidite ligand. Key elements for the efficiency of the process are the use of DABCO as borane-trapping reagent as well as substantial kinetic resolution, which was found to enhance the stereochemical outcome of the reaction.

Downloads

Published

2010-03-31