Light-Activatable Nucleic Acids 'Caged' at the Nucleobases

Authors

  • Maximilian Buff
  • Timo Mack
  • Alexander Heckel

DOI:

https://doi.org/10.2533/chimia.2009.261

Keywords:

Aptamers, Caged compounds, Light activation, Light trigger, Rnai

Abstract

The attachment of photolabile groups to biologically active molecules offers a very versatile way to put a biological effect under the control of an external trigger signal and thus confers spatiotemporal and dose control to this effect. Over the last years we have prepared a number of oligonucleotide derivatives that are modified in such a way. These derivatives are usually referred to as 'caged compounds' and in particular our photolabile 'caging groups' are located at the nucleobases of oligonucleotides so that the Watson–Crick interaction is temporarily impossible. Thus several nucleic acid-based applications have now become controllable with light.

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Published

2009-05-27