Interaction of Novel Metal Complexes with DNA: Synthetic and Structural Aspects

Authors

  • Bernhard Spingler
  • Chiara Da Pieve
  • Alfredo Medina-Molner
  • Philipp M. Antoni
  • Maria Grazia Santangelo

DOI:

https://doi.org/10.2533/chimia.2009.153

Keywords:

Bioinorganic chemistry, Crystal structures, Mono- and dinuclear metal complexes, Synthetic chemistry, Z-dna

Abstract

Metal ions bind to nucleic acids at various positions. This binding can be modulated by using metal complexes with appropriate ligands. Novel mono- and especially dinuclear metal complexes could be a powerful tool to detect rare, but still physiologically relevant, forms of DNA, e.g. the left-handed Z-DNA. In this review, our recent research activities in this area of bioinorganic chemistry are summarized. A special emphasis is laid on the synthetic challenges that arose upon the synthesis of the polyamine ligands. Further, some rather unusual approaches to elucidate the solution structure of copper bound to guanosine monophosphate with the help of pulsed EPR techniques like ENDOR and HYSCORE are described.

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Published

2009-03-25

How to Cite

[1]
B. Spingler, C. Da Pieve, A. Medina-Molner, P. M. Antoni, M. G. Santangelo, Chimia 2009, 63, 153, DOI: 10.2533/chimia.2009.153.