New Practical Synthesis of the Exceptional Musk Odorants (R)-Muscone and (R,Z)-5-Muscenone
DOI:
https://doi.org/10.2533/chimia.2008.489Keywords:
Aldol reaction, Amino alcohol, Asymmetric synthesis, Dynamic kinetic resolution, EliminationAbstract
Herein we describe a short and practical synthesis of the exceptional musk odorants (R)-muscone and (R,Z)-5-muscenone from a readily available achiral macrocyclic diketone. The key step of the synthesis is the first sodium N-methylephedrate mediated enantioselective aldol condensation reaction (up to 76% ee). This new type of reaction proceeds via a dynamic kinetic resolution of an aldol intermediate.Downloads
Published
2008-06-25
Issue
Section
Scientific Articles
License
Copyright (c) 2008 Swiss Chemical Society
![Creative Commons License](http://i.creativecommons.org/l/by-nc/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
[1]
O. Knopff, J. Kuhne, Chimia 2008, 62, 489, DOI: 10.2533/chimia.2008.489.