Formation of All-Carbon Quaternary Centers by Copper-Catalyzed Asymmetric Conjugate Addition

Authors

  • Alexandre Alexakis
  • Magali Vuagnoux-d'Augustin
  • David Martin
  • Stefan Kehrli
  • Laetitia Palais
  • Hélène Hénon
  • Christine Hawner

DOI:

https://doi.org/10.2533/chimia.2008.461

Keywords:

Aluminium, Asymmetry, Catalysis, Conjugate addition, Copper, Magnesium, Zinc

Abstract

This mini-review deals with a special, and challenging, aspect of the asymmetric conjugate addition: the formation of all-carbon quaternary centers by reaction with Michael acceptors bearing a polysubstituted unsaturation. Only copper catalysts allow this transformation, along with a careful choice of primary organometallics and chiral ligand. The resulting adducts are useful intermediates for the synthesis of more complex natural products.

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Published

2008-06-25

Issue

Section

Scientific Articles

How to Cite

[1]
A. Alexakis, M. Vuagnoux-d’Augustin, D. Martin, S. Kehrli, L. Palais, H. Hénon, C. Hawner, Chimia 2008, 62, 461, DOI: 10.2533/chimia.2008.461.