Formation of All-Carbon Quaternary Centers by Copper-Catalyzed Asymmetric Conjugate Addition
DOI:
https://doi.org/10.2533/chimia.2008.461Keywords:
Aluminium, Asymmetry, Catalysis, Conjugate addition, Copper, Magnesium, ZincAbstract
This mini-review deals with a special, and challenging, aspect of the asymmetric conjugate addition: the formation of all-carbon quaternary centers by reaction with Michael acceptors bearing a polysubstituted unsaturation. Only copper catalysts allow this transformation, along with a careful choice of primary organometallics and chiral ligand. The resulting adducts are useful intermediates for the synthesis of more complex natural products.Downloads
Published
2008-06-25
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Scientific Articles
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Copyright (c) 2008 Swiss Chemical Society
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
[1]
A. Alexakis, M. Vuagnoux-d’Augustin, D. Martin, S. Kehrli, L. Palais, H. Hénon, C. Hawner, Chimia 2008, 62, 461, DOI: 10.2533/chimia.2008.461.