Ferrocifens and Ferrocifenols as New Potential Weapons against Breast Cancer

Authors

  • Anh Nguyen
  • Anne Vessières
  • Elizabeth A. Hillard
  • Siden Top
  • Pascal Pigeon
  • Gérard Jaouen

DOI:

https://doi.org/10.2533/chimia.2007.716

Keywords:

Bioorganometallic chemistry, Breast cancer, Ferrocene, Iron, Serms

Abstract

Depending on the presence or absence of the estrogen receptor in the cells, breast cancer today is often treated by endocrine therapy (tamoxifen) or chemotherapy, respectively. We present now a new paradigm for breast cancer treatment, taking advantage of concepts in bioorganometallic chemistry. In this way, we have synthesized molecules containing an organometallic moiety (ferrocene), and a biovector (hydroxytamoxifen), yielding compounds which display a new therapeutic spectrum consisting of antiestrogenicity and cytotoxicity. A structure–activity relationship study has shown that a ferrocene group, linked to a para-phenol group by a conjugated spacer, is a necessary motif for strong cytotoxic effects to be observed.

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Published

2007-11-28

Issue

Section

Scientific Articles

How to Cite

[1]
A. Nguyen, A. Vessières, E. A. Hillard, S. Top, P. Pigeon, G. Jaouen, Chimia 2007, 61, 716, DOI: 10.2533/chimia.2007.716.