Ferrocifens and Ferrocifenols as New Potential Weapons against Breast Cancer
DOI:
https://doi.org/10.2533/chimia.2007.716Keywords:
Bioorganometallic chemistry, Breast cancer, Ferrocene, Iron, SermsAbstract
Depending on the presence or absence of the estrogen receptor in the cells, breast cancer today is often treated by endocrine therapy (tamoxifen) or chemotherapy, respectively. We present now a new paradigm for breast cancer treatment, taking advantage of concepts in bioorganometallic chemistry. In this way, we have synthesized molecules containing an organometallic moiety (ferrocene), and a biovector (hydroxytamoxifen), yielding compounds which display a new therapeutic spectrum consisting of antiestrogenicity and cytotoxicity. A structure–activity relationship study has shown that a ferrocene group, linked to a para-phenol group by a conjugated spacer, is a necessary motif for strong cytotoxic effects to be observed.Downloads
Published
2007-11-28
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Scientific Articles
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Copyright (c) 2007 Swiss Chemical Society
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How to Cite
[1]
A. Nguyen, A. Vessières, E. A. Hillard, S. Top, P. Pigeon, G. Jaouen, Chimia 2007, 61, 716, DOI: 10.2533/chimia.2007.716.