Optical Detection of Very Small Nonfluorescent Nanoparticles

Authors

  • Vahid Sandoghdar
  • Enrico Klotzsch
  • Volker Jacobsen
  • Alois Renn
  • Ulf Håkanson
  • Mario Agio
  • Ilja Gerhardt
  • Johannes Seelig
  • Gert Wrigge

DOI:

https://doi.org/10.2533/chimia.2006.761

Keywords:

Interferometric detection, Label-free, Nanoparticle, Optical microscopy, Particle tracking

Abstract

We discuss an interferometric method for the optical detection of very small nonfluorescent nanoparticles. In particular, we show that single gold nanoparticles with a diameter as small as 5 nm can be detected. We discuss the potential of such tiny particles as optical labels for biological studies. Furthermore, we show that our interferometric method can be also used for the detection and tracking of unlabelled biological nano-entities such as viruses or microtubuli.

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Published

2006-11-29

Issue

Vol. 60 No. 11 (2006): Nanoanalysis

Section

Scientific Articles

License

Copyright (c) 2006 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
V. Sandoghdar, E. Klotzsch, V. Jacobsen, A. Renn, U. Håkanson, M. Agio, I. Gerhardt, J. Seelig, G. Wrigge, Chimia 2006, 60, 761, DOI: 10.2533/chimia.2006.761.