Mitochondrial Toxicity of Drugs

Authors

  • Liliane Todesco
  • Katri Waldhauser
  • Stephan Krähenbühl

DOI:

https://doi.org/10.2533/000942906777675083

Keywords:

Apoptosis, Drug toxicity, Mitochondria, Necrosis, Beta-oxidation, Respiratory chain

Abstract

Mitochondria are important targets of drug toxicity. A variety of drugs has been shown to affect the electron transport chain, coupling of oxidative phosphorylation, ?-oxidation or other mitochondrial functions. Such damaging events may lead to the opening of a large pore across the mitochondrial membranes – the membrane permeability transition pore – eventually leading to apoptosis or necrosis of cells, depending on the cellular ATP content. Such drugs may therefore lead to organ damage, particularly in the liver, kidney, heart or skeletal muscle.

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Published

2006-02-23

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