Preparation of Modified RNA Sequences for Biological Research
DOI:
https://doi.org/10.2533/000942905777675633Keywords:
Ligation, Nucleic acids, Organic synthesis, Phosphoramidites, RnaAbstract
Our group is working on the development of reliable access to biologically relevant, long, and modified RNA sequences. Here, we briefly present the chemical synthesis of such sequences with 2?-O-triisopropylsilyloxymethyl (= 2?-O-tom) protected ribonucleoside phosphoramidites, their template-directed enzymatic ligation, and some examples of modified nucleotides, designed to promote structural and biological studies.Downloads
Published
2005-11-01
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Scientific Articles
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Copyright (c) 2005 Swiss Chemical Society
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How to Cite
[1]
S. Pitsch, P. Wenter, A. Stutz, L. Reymond, S. Porcher, A. Peer, E. Muller, M. Meyyappan, F. Meylan, C. Denarie, D. Ackermann, X. Wu, Chimia 2005, 59, 808, DOI: 10.2533/000942905777675633.