2-Styryl-pyridines and 2-(3,4-Dihydro-naphthalen-2-yl)pyridines as Potent NR1/2B Subtype Selective NMDA Receptor Antagonists
Keywords:Neurodegeneration, Nmda, Nr1/2b antagonists, Structure-activity relationship
AbstractA series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists that are selective (vs. ?1 and M1 receptors) and are active in vivo .
How to Cite
B. Buettelmann, A. Alanine, A. Bourson, R. Gill, M.-P. Heitz, V. Mutel, E. Pinard, G. Trube, R. Wyler, Chimia 2004, 58, 630, DOI: 10.2533/000942904777677579.
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