Perfluorinated Brønsted 'Superacids': Powerful Catalysts for the Preparation of Vitamin E

Authors

  • Thomas Netscher
  • Werner Bonrath
  • Alois Haas
  • Eike Hoppmann
  • Horst Pauling

DOI:

https://doi.org/10.2533/000942904777678181

Keywords:

Biphasic catalysis, Friedel-crafts alkylation, Perfluorinated nh-acidic imides, &alpha-tocopherol, Tris(perfluoroalkylsulfonyl) methanes

Abstract

The key-step in the industrial synthesis of (all-rac)-?-tocopherol (synthetic vitamin E) is the condensation reaction of trimethylhydroquinone with the C20 building block isophytol. For this Friedel-Crafts-type reaction, perfluorinated NH- and CH-acidic compounds (perfluoroalkyl(aryl)sulfonyl imides and methides) have been applied as excellent catalysts, preferably in biphasic solvent systems.

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Published

2004-03-01

Issue

Vol. 58 No. 3 (2004): Fluorine in the Life Science Industry

Section

Scientific Articles

License

Copyright (c) 2004 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
T. Netscher, W. Bonrath, A. Haas, E. Hoppmann, H. Pauling, Chimia 2004, 58, 153, DOI: 10.2533/000942904777678181.