Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination
DOI:
https://doi.org/10.2533/000942904777678118Keywords:
Antidepressant, Bioisosterism, Metabolism, Pseudohalogen, Ultrasonic vocalisationAbstract
Fluorine substitution modifies structural attributes and often induces unexpected effects. When substituting fluorine with cyano in position 5 of the indole in indole-butyl-amines, the properties of the compounds proved to be very comparable. In vitro target-profile, metabolism, and in vivo activity in the ultrasonic vocalisation test indicate bioisosterism between the two substituents.Downloads
Published
2004-03-01
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Scientific Articles
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Copyright (c) 2004 Swiss Chemical Society
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How to Cite
[1]
T. Heinrich, H. Böttcher, G. D. Bartoszyk, H. Schwartz, S. Anzali, J. März, H. E. Greiner, C. A. Seyfried, Chimia 2004, 58, 143, DOI: 10.2533/000942904777678118.