?-Fluoro-Benzylphosphonates as Reagents for the Preparation of 1-Fluoro-1-Aryl Alkenes and ?-Fluorostilbenes

Authors

  • Thomas Allmendinger
  • Roger Fujimoto
  • Fabrizio Gasparini
  • Walter Schilling
  • Yoshi Satoh

DOI:

https://doi.org/10.2533/000942904777678217

Keywords:

Fluoro-benzylphosphonates, Fluoroolefins, Horner-wadsworth-emmons olefination

Abstract

The preparation of several fluoro-benzylphosphonates Ar-CHF-PO(OEt)2 and their Wadsworth-Emmons type olefination with aldehydes and ketones are described affording fluorostyrenes and fluorostilbenes. Some of these compounds are incorporated into target molecules tested as drug candidates.

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Published

2004-03-01

Issue

Vol. 58 No. 3 (2004): Fluorine in the Life Science Industry

Section

Scientific Articles

License

Copyright (c) 2004 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
T. Allmendinger, R. Fujimoto, F. Gasparini, W. Schilling, Y. Satoh, Chimia 2004, 58, 133, DOI: 10.2533/000942904777678217.