Physical and Molecular Properties of Agrochemicals: An Analysis of Screen Inputs, Hits, Leads, and Products

Abstract

This work provides a comprehensive overview of agrochemical properties in terms of the way they change during progression from screen hit to product and in terms of their limits as expressed in modern commercial products. Most herbicides and fungicides readily meet the Lipinski 'rule of five' criteria for drug-like compounds with many meeting the more constrained limits reported for pharmaceutical leads.