Synthesis and Herbicidal Activity of Phenylpyridines – A New Lead
DOI:
https://doi.org/10.2533/000942903777678650Keywords:
Phenylpyridines, Protoporphyrinogen-ix-oxidase inhibitors, Sar, Suzuki-couplingAbstract
Novel phenylpyridines were synthesized based on molecular modeling oriented design by superposition of herbicidal phenyl-uracils, -indazoles, and diphenylethers. Their preparation follows Suzuki-type coupling conditions of reactive 2-chloro-pyridines with appropriate 2,5-substituted 4-chloro-phenyl boronic acids. Depending on the nature of substituents in the pyridine, and in particular the phenyl group, a large number of derivatives are readily accessible. Besides open-chain phenylpyridines also anellated compounds, such as pyridine-substituted 2H-1,4-benzothiazin-3(4H)-one or 3,4-dihydro-1H-quinolin-2-one, were prepared. Phenylpyridines act by inhibition of protoporphyrinogen-IX-oxidase. Their synthesis will be described in conjunction with structure–activity relationships. Phenylpyridines are highly active against many important broadleaf and grass weed species under pre- and – in particular – post-emergent conditions.Downloads
Published
2003-11-01
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Scientific Articles
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Copyright (c) 2003 Swiss Chemical Society
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
[1]
Chimia 2003, 57, 715, DOI: 10.2533/000942903777678650.