The Crocacins: Novel Natural Products as Leads for Agricultural Fungicides

Authors

  • Patrick J. Crowley
  • Paul A. Worthington
  • Joe Swanborough
  • Olivia-Anabelle Sageot
  • Gordon R. Munns
  • Ingrid M. Devillers
  • Christopher R.A. Godfrey
  • Kevin Gillen
  • Ian H. Aspinall
  • John Williams

DOI:

https://doi.org/10.2533/000942903777678669

Keywords:

Agrochemical, Crocacin, Fungicide, Natural product, Respiration

Abstract

A short route to the synthesis of analogues of the antifungal but unstable natural product crocacin D was developed. A wide range of compounds were made in which the complex side chain was replaced by simple aromatic units, and many of them showed high activity in a mitochondrial beef heart respiration assay. Some of these compounds were active against plant pathogenic fungi of agricultural importance in glasshouse tests. In order to find compounds with greater stability than the natural crocacins, the photolabile (Z)-enamide was replaced with many different moieties, but none gave rise to useful fungicidal activity.

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Published

2003-11-01

Issue

Vol. 57 No. 11 (2003): Crop Protection Research

Section

Scientific Articles

License

Copyright (c) 2003 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
P. J. Crowley, P. A. Worthington, J. Swanborough, O.-A. Sageot, G. R. Munns, I. M. Devillers, C. R. Godfrey, K. Gillen, I. H. Aspinall, J. Williams, Chimia 2003, 57, 685, DOI: 10.2533/000942903777678669.