The Synthesis of a Pyrazol Analogon of Porphobilinogen with the Help of the Mukaiyama Aldol Reaction

Authors

  • André Chaperon
  • Hugo Bertschy
  • Anne-Laurence Franz-Schrumpf
  • Bertrand Hugelet
  • Antonia Neels
  • Helen Stoeckli-Evans
  • Reinhard Neier

DOI:

https://doi.org/10.2533/000942903777678812

Keywords:

Biomimetic synthesis, Mukaiyama aldol reaction, Porphobilinogen, Silyl enol ether

Abstract

The synthesis of a pyrazol analogon of porphobilinogen is described. The Mukaiyama crossed aldol reaction is the key step of our approach. The retrosynthetic analysis follows the mechanism for the biosynthesis of porphobilinogen initially proposed by Shemin.

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Published

2003-10-01

Issue

Vol. 57 No. 10 (2003): Chemistry in Neuchatel

Section

Scientific Articles

License

Copyright (c) 2003 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
A. Chaperon, H. Bertschy, A.-L. Franz-Schrumpf, B. Hugelet, A. Neels, H. Stoeckli-Evans, R. Neier, Chimia 2003, 57, 601, DOI: 10.2533/000942903777678812.