The Synthesis of a Pyrazol Analogon of Porphobilinogen with the Help of the Mukaiyama Aldol Reaction

André Chaperon; Hugo Bertschy; Anne-Laurence Franz-Schrumpf; Bertrand Hugelet; Antonia Neels; Helen Stoeckli-Evans; Reinhard Neier

doi:10.2533/000942903777678812

The Synthesis of a Pyrazol Analogon of Porphobilinogen with the Help of the Mukaiyama Aldol Reaction

Authors

André Chaperon
Hugo Bertschy
Anne-Laurence Franz-Schrumpf
Bertrand Hugelet
Antonia Neels
Helen Stoeckli-Evans
Reinhard Neier

DOI:

https://doi.org/10.2533/000942903777678812

Keywords:

Biomimetic synthesis, Mukaiyama aldol reaction, Porphobilinogen, Silyl enol ether

Abstract

The synthesis of a pyrazol analogon of porphobilinogen is described. The Mukaiyama crossed aldol reaction is the key step of our approach. The retrosynthetic analysis follows the mechanism for the biosynthesis of porphobilinogen initially proposed by Shemin.