Exploiting the Second Coordination Sphere: Proteins as Host for Enantioselective Catalysis

Thomas R. Ward; Jérôme Collot; Julieta Gradinaru; Andreas Loosli; Myriem Skander; Christophe Letondor; Edith Joseph; Gérard Klein

doi:10.2533/000942903777678722

Exploiting the Second Coordination Sphere: Proteins as Host for Enantioselective Catalysis

Authors

Thomas R. Ward
Jérôme Collot
Julieta Gradinaru
Andreas Loosli
Myriem Skander
Christophe Letondor
Edith Joseph
Gérard Klein

DOI:

https://doi.org/10.2533/000942903777678722

Keywords:

Artificial metalloenzymes, Enantioselective catalysis, Second coordination sphere

Abstract

With the aim of exploring the role of the second coordination sphere in enantioselective catalysis, achiral organometallic catalyst precursors are anchored in proteins via non-covalent interactions. A chemogenetic procedure allows the activity and the enantioselectivity of the artificial metalloenzymes to be optimized, to yield hybrid catalysts with features reminiscent both of enzymatic and homogeneous catalysts.

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Published

2003-10-01

How to Cite

[1]

T. R. Ward, J. Collot, J. Gradinaru, A. Loosli, M. Skander, C. Letondor, E. Joseph, G. Klein, Chimia 2003, 57, 586, DOI: 10.2533/000942903777678722.