Peptide Receptors – From Selective Molecular Recognition Towards Catalytic Activity

Abstract

The development of diketopiperazine receptors, a class of two-armed receptors that bind peptides with high selectivity, has been achieved by a combination of on-bead combinatorial binding assays and conformational analysis using X-ray crystal structure analysis and NMR spectroscopy. Furthermore, a general method for the discovery of catalysts within split-and-mix libraries has been developed that is based on the co-immobilization of the potential catalyst and one reactant on the same bead.