Peptide Receptors – From Selective Molecular Recognition Towards Catalytic Activity

Authors

  • Helma Wennemers

DOI:

https://doi.org/10.2533/000942903777679352

Keywords:

Catalysis, Combinatorial chemistry, Molecular recognition, Peptide receptors, Split-and-mix libraries

Abstract

The development of diketopiperazine receptors, a class of two-armed receptors that bind peptides with high selectivity, has been achieved by a combination of on-bead combinatorial binding assays and conformational analysis using X-ray crystal structure analysis and NMR spectroscopy. Furthermore, a general method for the discovery of catalysts within split-and-mix libraries has been developed that is based on the co-immobilization of the potential catalyst and one reactant on the same bead.

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Published

2003-05-01

How to Cite

[1]
H. Wennemers, Chimia 2003, 57, 237, DOI: 10.2533/000942903777679352.

Issue

Section

Scientific Articles