From the DNA Gyrase Inhibitor Cyclothialidine to a New Class of Antibacterial Agents

Authors

  • Erwin Goetschi
  • Fabienne Ricklin
  • Peter Reindl
  • Raffaello Masciadri
  • Thomas Luebbers
  • Helmut Link
  • Dirk Kostrewa
  • Paul Hebeisen
  • Hans Gmuender
  • Peter Angehrn
  • Frank-Peter Theil

DOI:

https://doi.org/10.2533/000942903777679505

Keywords:

Antibacterials, Cyclothialidine, Dna gyrase inhibitor, Natural products

Abstract

Cyclothialidine (Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from S. filipinensis NR0484. In this account we describe the identification of potent antibacterials structurally derived from this virtually neat enzyme inhibitor.

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Published

2003-04-01

Issue

Vol. 57 No. 4 (2003): Laureates: Awards and Honors (SCS)

Section

Scientific Articles

License

Copyright (c) 2003 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
E. Goetschi, F. Ricklin, P. Reindl, R. Masciadri, T. Luebbers, H. Link, D. Kostrewa, P. Hebeisen, H. Gmuender, P. Angehrn, F.-P. Theil, Chimia 2003, 57, 184, DOI: 10.2533/000942903777679505.