Towards the Directed Evolution of Hybrid Catalysts

Authors

  • Manfred T. Reetz
  • Martin Rentzsch
  • Andreas Pletsch
  • Matthias Maywald

DOI:

https://doi.org/10.2533/000942902777679920

Keywords:

Chemical modification, Directed evolution, Enzymes, Hybrid catalysts, Transition metal catalysis

Abstract

The first step in applying the recently proposed concept concerning the application of directed evolution to the creation of selective hybrid catalysts is described, specifically the covalent attachment of Mn-salen moieties and of Cu-, Pd-, and Rh-complexes of dipyridine derivatives as well as the implantation of a diphosphine moiety in a protein, future steps being cycles of mutagenesis/screening.

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Published

2002-12-01