Bioorganic Chemistry of Rigid-Rod Molecules: Adventures with p-Oligophenyls

Authors

  • Yoann Baudry
  • Bodo Baumeister
  • Gopal Das
  • David Gerard
  • Stefan Matile
  • Naomi Sakai
  • Abhigyan Som
  • Nathalie Sordé
  • Pinaki Talukdar

DOI:

https://doi.org/10.2533/000942902777679948

Keywords:

Antibiotics, Beta-barrels, Enzyme mimics, Ion channels, Molecular recognition, Sensors

Abstract

Studies on the usefulness of rigid-rod molecules to address pertinent questions of biological relevance are summarized. Emphasis is placed on (a) the supramolecular functional plasticity of p-octiphenyl ?-barrels expressed in molecular recognition (adaptable synthetic hosts), molecular translocation (adaptable synthetic ion channels) and molecular transformation (esterases, RNases), (b) molecular recognition of polarized membranes by rigid push-pull rods, as well as (c) the synthetic organic chemistry of rigid-rod molecules.

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Published

2002-12-01