Protecting Groups for the Synthesis of Ribonucleic Acids

Authors

  • Stefan Pitsch Laboratorium für Organische Chemie, ETH Zentrum, Universitätstr. 16, CH-8092 Zürich

DOI:

https://doi.org/10.2533/chimia.2001.320

Keywords:

Nucleic acids, Protecting groups, Phosphoramidites, Rna

Abstract

Methods for the regioselective introduction of alkoxymethyl-groups into the 2'-O-position of 5'-O-dimethoxytritylated, nucleobase-protected ribonucleosides and for the N-alkyloxycarbonylation of adenine and guanine nucleosides were developed. These methods were used for the preparation of RNA-phosphoramidites carrying novel fluoride- and photolabile sugar and nucleobase protecting groups.

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Published

2001-04-25

Issue

Vol. 55 No. 4 (2001): Chemical Biology / Biological Chemistry

Section

Scientific Articles

License

Copyright (c) 2001 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
Chimia 2001, 55, 320, DOI: 10.2533/chimia.2001.320.