Protecting Groups for the Synthesis of Ribonucleic Acids
DOI:
https://doi.org/10.2533/chimia.2001.320Keywords:
Nucleic acids, Protecting groups, Phosphoramidites, RnaAbstract
Methods for the regioselective introduction of alkoxymethyl-groups into the 2'-O-position of 5'-O-dimethoxytritylated, nucleobase-protected ribonucleosides and for the N-alkyloxycarbonylation of adenine and guanine nucleosides were developed. These methods were used for the preparation of RNA-phosphoramidites carrying novel fluoride- and photolabile sugar and nucleobase protecting groups.
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2001-04-25
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Copyright (c) 2001 Swiss Chemical Society
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How to Cite
[1]
S. Pitsch, Chimia 2001, 55, 320, DOI: 10.2533/chimia.2001.320.