Design and Evaluation of Oligonucleotide Analogues

Authors

  • Christian J. Leumann Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH-3012 Bern

DOI:

https://doi.org/10.2533/chimia.2001.295

Keywords:

Conformational restriction, Dna, Oligonucleotide analogues, Rna, Triple helix

Abstract

This article contains a short account of the chemical and biophysical properties of the oligonucleotide analogues bicyclo-DNA, tricyclo-DNA, [3.2.1]-DNA, [3.2.1]amide-DNA and the PNA analogue OPA, recently developed in our laboratory. Emphasis is given to various aspects of conformational restriction as a designer tool for enhancing the performance of oligonucleotide analogues and for exploring the supramolecular chemistry of DNA. A short summary of current problems in the field of DNA triple-helix chemistry as well as contributions from our laboratory in this area concludes this communication.

Downloads

Published

2001-04-25

Issue

Vol. 55 No. 4 (2001): Chemical Biology / Biological Chemistry

Section

Scientific Articles

License

Copyright (c) 2001 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
C. J. Leumann, Chimia 2001, 55, 295, DOI: 10.2533/chimia.2001.295.