Conformationally Restricted Oligonucleotide Analogues 'Made in Bern': A Mini Review

Authors

  • Christian J. Leumann Department of Chemistry and Biochemistry, University of Bern, Freiestr. 3, 3012 Bern

DOI:

https://doi.org/10.2533/chimia.2001.1041

Keywords:

Conformational restriction, DNA, Nucleosides, Oligonucleotides, RNA

Abstract

In our search for novel oligonucleotide analogues for use in therapy and DNA-based diagnostics we explored the concept of conformational preorganization as a means to improve duplex stability with complementary DNA and RNA. This research effort has led to a number of novel DNA analogues and has contributed to a deeper understanding of the interrelation between the structure of nucleosides and the properties of corresponding oligonucleotides. Some of these analogues show interesting biological properties. This article is a short review summarizing the properties of bicyclo-DNA and tricyclo-DNA, developed in our laboratory.

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Published

2001-12-19