Bioanalytische Festphasenextraktion: Ein Klassiker in einem neuen, massgeschneiderten Gewand

Bioanalytical solid-phase extraction: A classic in a new, tailor-made garment

Abstract

In bioanalytical HPLC, optimization of sample pretreatment should be directed towards improved selectivity, high sample through-put and total automation with simultaneous cost-reduction and improvment of the analytical quality. These requirements can be accomplished by integrating the extractive sample clean-up process (Solid-Phase Extraction; SPE) into the HPLC-system. For this purpose, tailor-made adsorbents (Restricted Access Materials, RAM; Molecular Imprinted Polymers, MIP) are used as precolumn packings.