Functional Brain Receptor Imaging with Positron Emission Tomography
DOI:
https://doi.org/10.2533/chimia.2000.622Keywords:
Dopamine and serotonin transporters, Ecstasy, Epibatidine, Pet, Pharmaceutical chemistryAbstract
A new cocaine derivative for imaging the dopamine transporter has been developed. Measurements of radioligand binding of 11C-(+)-McN-5652 in vivo with PET suggests that ecstasy interacts directly with the serotonin reuptake sites and that a single oral dose of ecstasy (1.5 mg/kg) does not cause any changes in the serotonin transporter density in the human brain. Finally, a number of epibatidine derivatives have been developed as ligands to study the central nAChRs in vivo, however, toxicity studies prevented further clinical use.
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Published
2000-11-29
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Scientific Articles
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Copyright (c) 2000 Swiss Chemical Society
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
[1]
Chimia 2000, 54, 622, DOI: 10.2533/chimia.2000.622.