The Central Cleavage of ?,?-Carotene – A Supramolecular Mimic of Enzymatic Catalysis

Authors

  • Wolf-D. Woggon

DOI:

https://doi.org/10.2533/chimia.2000.564

Keywords:

Carotenoids, Catalysis, Cyclodextrins, Enzymes, Ru-porphyrins, Supramolecular chemistry

Abstract

The enzyme ?,?-carotene 15,15?-dioxygenase which cleaves ?,?-carotene to retinal (provitamin A) has been identified for the first time in chicken intestinal mucosa and subsequently sequenced and expressed in two different cell lines. To mimic this unusual metabolism a supramolecular receptor has been synthesized which binds ?,?-carotene with Ka = 8.3 × 106 M?1 and it was shown that the corresponding oxo-ruthenium complex catalyzes the selective cleavage of carotenoids.

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Published

2000-10-25

Issue

Vol. 54 No. 10 (2000): Supramolecular Chemistry

Section

Scientific Articles

License

Copyright (c) 2000 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
W.-D. Woggon, Chimia 2000, 54, 564, DOI: 10.2533/chimia.2000.564.