SASRIN™, a Versatile Tool in Peptide Synthesis and Solid-Phase Organic Chemistry

Authors

  • Monika Mergler
  • Jacques Gosteli
  • Peter Grogg
  • Rolf Nyfeler
  • Rudolf Tanner

DOI:

https://doi.org/10.2533/chimia.1999.29

Abstract

The synthesis of the 4-(3-methoxy-4-(hydroxymethyl)phenoxymethyl) derivative of polystyrene-co-divinylbenzene (SASRIN™), its derivatives and its application in solid-phase peptide synthesis will be briefly reviewed in this paper. Solid-phase synthesis of fully protected peptide fragments may be the most important, but by far not the only application, as cleavage with nucleophiles or solid-phase synthesis on SASRIN derivatives will yield a range of useful C-terminally modified peptides, such as peptide hydrazides or p-nitroanilides.

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Published

1999-02-24

Issue

Section

Scientific Articles