Planned Releases of Genetically Modified Organisms into the Environment: the Evolution of Safety Considerations

Authors

  • Othmar Käppeli
  • Lillian Auberson

DOI:

https://doi.org/10.2533/chimia.1998.137

Abstract

Issues of safety and risk have taken the foreground in discussions on the deliberate release of genetically modified organisms. In most cases, the organisms being introduced into the environment are modified versions of familiar organisms with a long history of safe use and are expected to have no direct adverse effects for human health or for the environment. However, there is legitimate concern about the environmental fate of these organisms, in particular, about the genetic information which they carry. In the past, discussions of technological risk have often been based on the terminology and logic of the familiar risk-assessment strategy developed for characterizing risks from hazardous chemical processes. While the direct transfer of this assessment model to evaluating contained biotechnological processes has been successful, attempts at molding the model to the requirements of open systems have been unsatisfactory. To be meaningful, the safety evaluation for environmental releases must accomodate the distinguishing features of this open system: the lack of an intrinsic hazardous property, the lack of quantitative thresholds for adverse effects, and the lack of a common currency in which to express potential damages. A survey of risk-assessment strategies in the chemical and biotechnological sectors is presented here. This will provide the necessary background to understanding the current situation of assessing and communicating the risks associated with the reintroduction of familiar organisms into environments where they were already naturally present.

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Published

1998-04-29

How to Cite

[1]
O. Käppeli, L. Auberson, Chimia 1998, 52, 137, DOI: 10.2533/chimia.1998.137.

Issue

Section

Scientific Articles