Catalytic Enantioselective Reactions from Research to Application. Diarylmethanol-Containing Auxiliaries as a Study Case

Abstract

Chiral auxiliaries – in the broadest possible definition of the term – can be obtained by Grignard reactions of Aryl-MgX with chiral esters R*CO₂R. The products formed all contain a diarylmethanol structural moiety. They can be used in stoichiometric and catalytic enantioselective reactions, preferably as ligands on metal centers. They have also found applications for enantioselective inclusions, for solid-phase reactions, and for liquid-crystal preparations.