Research Topics

Abstract

Quantum-mechanical calculations have been applied to predict thermodynamic and reactivity properties of unknown organic molecules, being stable compounds or reactive intermediates. Through synthesis some of the theoretical systems become real compounds that can be synthons (synthetic intermediates) or chirons (optically pure synthetic intermediates) useful in the preparation of natural products and analogues of biological interest (anti-cancer, anti-virus, antibiotic, anti-diabetes agents). Our interests concentrate on remote substituent effects as we want to play with them together with polyfunctional systems and reactions that constitute new synthetic approaches. These have to be convergent, highly stereoselective, and versatile (applicable to a large variety of derivatives: molecular diversity). We often rely on tandem reactions or/and reaction cascades. Sometimes the new compounds and their new reactions send us back to the theory and to mechanistic studies.