Azasugar Glycosidase Inhibitors: Useful Tools for Glycobiologists

Abstract

Glycosidase inhibitors are moving increasingly as potential agents for the treatment of diseases by altering glycosylation or catabolism of glycoconjugates. The azasugars, a potent class of inhibitors have received much attention as tools for therapeutic investigation and in understanding of certain biological processes such as glycoprotein processing and enzymatic mechanisms. In this paper, we present some new synthetic azasugar compounds which show interesting activity as glycosidase inhibitors.