Development of a Process to Prepare 2-Cyanopyrimidine on Commercial Scale

Abstract

2-Chloropyrimidine is converted to 2-cyanopyrimidine under very mild conditions in nearly quantitative yield using 1,4-diazabicyclo[2.2.2]octane as catalyst. The development of the process for commercial batch production of 2-cyanopyrimidine regarding processing of the materials in technical equipment, process safety, conservation, economic raw material use and work load is described.