Synthesis of the HIV-Proteinase Inhibitor Saquinavir: A Challenge for Process Research
DOI:
https://doi.org/10.2533/chimia.1996.532Abstract
The task of process research, namely developing efficient, economically and technically as well as ecologically feasible syntheses in time, is demonstrated on the HIV-proteinase inhibitor Saquinavir, a complex molecule comprising six stereo-centres. Based on the first 26-step research synthesis furnishing a 10% overall yield, process research established a new, short 11-step synthesis affording a 50% overall yield.Downloads
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1996-11-27
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Scientific Articles
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Copyright (c) 1996 Swiss Chemical Society
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How to Cite
[1]
W. Göhring, S. Gokbale, H. Hilpert, F. Roessler, M. Schlageter, P. Vogt, Chimia 1996, 50, 532, DOI: 10.2533/chimia.1996.532.