Synthesis of the HIV-Proteinase Inhibitor Saquinavir: A Challenge for Process Research

Authors

  • Wolfgang Göhring
  • Surendra Gokbale
  • Hans Hilpert Pharmaceutical Division Process Research, F. Hoffmann-La Roche Ltd., CH-4070 Basel
  • Felix Roessler
  • Markus Schlageter
  • Peter Vogt

DOI:

https://doi.org/10.2533/chimia.1996.532

Abstract

The task of process research, namely developing efficient, economically and technically as well as ecologically feasible syntheses in time, is demonstrated on the HIV-proteinase inhibitor Saquinavir, a complex molecule comprising six stereo-centres. Based on the first 26-step research synthesis furnishing a 10% overall yield, process research established a new, short 11-step synthesis affording a 50% overall yield.

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Published

1996-11-27

Issue

Vol. 50 No. 11 (1996): The First 100 Years of the Roche Group

Section

Scientific Articles

License

Copyright (c) 1996 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
Chimia 1996, 50, 532, DOI: 10.2533/chimia.1996.532.