Nucleic Acid Ligands Based on Carbohydrates
AbstractSequence-specific nucleic acid ligands are important tools in chemistry and molecular biology and are thought to possess a considerable pharmaceutical potential. An overview of the structurally and mechanistically diverse approaches in the field with an emphasis on carbohydrates will be presented. Carbohydrates are just beginning to emerge as a novel class of nucleic acid binding compounds. The detailed study of the factors affecting the site-selectivity of some recently discovered antitumor antibiotics, e.g. calicheamicin, has shed a new light on the role thatoligosaccharides may play in nucleic acid recognition. Understanding these factors may aid in the rational design of novel nucleic acid ligands and their therapeutic application.
How to Cite
J. Hunziker, Chimia 1996, 50, 248, DOI: 10.2533/chimia.1996.248.
Copyright (c) 1996 Swiss Chemical Society
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