Die Entwicklung eines neuen, umweltgerechten Produktionsprozesses für Terbinafin

Authors

  • Ulrich Beutler
  • Jan Mazacek
  • Gerhard Penn Sandoz Pharma AG, Lichtstrasse 35, CH-4002 Basel
  • Berthold Schenkel
  • Daniel Wasmuth

DOI:

https://doi.org/10.2533/chimia.1996.154

Abstract

An efficient process for the production of terbinafine is described. Starting from (E)-I,3-dichloropropene, neohexene, and N-methyl-( I-naphthylmethyl)amine and using a palladium-catalyzed coupling methodology, terbinafine is produced exclusively as (E)-isomer in a convergent manner. The new process avoids the very toxic and nasty starting materials acrolein and phosphorus pentachloride used in the old process.

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Published

1996-04-24

Issue

Section

Scientific Articles