A Novel Synthesis of rac-5-(Hydroxymethyl)-1-(Tetrahydro-2'-oxofur-3'-yl)-1H-pyrrole-2-carboxaldehyde
DOI:
https://doi.org/10.2533/chimia.1993.230Abstract
A novel six-step synthesis of rac-5-(hydroxymethyl)-1-(tetrahydro-2'-oxo-fur-3'-yl)-1H-pyrrole-2-carboxaldehyde (rac-1) starting from 2-methylfuran has been developed. The key step is the formation of rac-2-methyl-1-(tetrahydro-2'-oxofur-3'- yl)-1H-pyrrole (rac-7) according to the Clauson-Kaas procedure. Subsequent Vilsmeier formylation, oxidation with lead tetraacetate, and enzymatic hydrolysis led to rac-1.
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1993-06-30
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Forschung
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Copyright (c) 1993 Swiss Chemical Society
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How to Cite
[1]
P. Hayoz, A. Aeby, C. Pasquier, R. Neier, Chimia 1993, 47, 230, DOI: 10.2533/chimia.1993.230.